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Diazepam has a half-life (t1/2?) of 20-50 hours, and desmethyldiazepam has a half-life of 30-200 hours. Diazepam is also found in nature.
Diazepam, marketed under brand names Valium, Stesolid, Diazemuls, Seduxen, Bosaurin, Diapam, Antenex and Apozepam) is a drug which is a benzodiazepine derivative.
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Due to the role of diazepam as a positive allosteric modulator of GABA, when it binds to benzodiazepine receptors it causes inhibitory effects.
Diazepam is a core medicine in the World Health Organization's "Essential Drugs List", which is a list of minimum medical needs for a basic health care system.
The benzodiazepines are also far less dangerous; death rarely results from diazepam overdose, except in cases where it is consumed with large amounts of other depressants (such as alcohol or other sedatives).
Diazepam is a core medicine in the World Health Organization's "Essential Drugs List", which is a list of minimum medical needs for a basic health care system. Diazepam was the second benzodiazepine to be invented by Leo Sternbach of Hoffmann-La Roche, and was approved for use in 1963. It is also used before certain medical procedures (such as endoscopies) to reduce tension and anxiety, and in some surgical procedures to induce amnesia to order valium.
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When diazepam is administered orally, it is rapidly absorbed and has a fast onset of action. After absorption, diazepam is redistributed into muscle and adipose tissue. In 1966, The Rolling Stones released the song "Mother's Little Helper", which is about a mother needing the "little yellow pill" to get through the day.
Diazepam is highly lipid-soluble, and is widely distributed throughout the body after administration. Diazepam is also found in nature.
Over the years, physicians, psychiatrists and neurologists have discovered many new off-label uses for diazepam, such as treatment of spastic paresis and palliative treatment of stiff-person syndrome. The benzodiazepines are also far less dangerous; death rarely results from diazepam overdose, except in cases where it is consumed with large amounts of other depressants (such as alcohol or other sedatives).
Diazepam appears to act on areas of the limbic system, thalamus and hypothalamus, inducing anxiolytic effects. Several plants, such as potato and wheat, contain trace amounts of naturally occurring diazepam and other benzodiazepines. Continual daily doses of diazepam will quickly build up to a high concentration in the body (mainly in adipose tissue), which will be far in excess of the actual dose for any given day.
This arises from the hyperpolarization of the postsynaptic membrane, due to the control exerted over negative chloride ions by GABAA receptors.
Peak plasma levels are achieved 30 minutes to 2 hours after oral administration.
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